Streptococcus pneumoniae

Antibiotic
% Susceptible
2010
% Susceptible
2012
% Susceptible
2014
% Susceptible
2016
% Susceptible
2018
Ampicillin
+
 + + + +
Azithromycin
+
 74
80
 86 71
Aztreonam
-
 -
-
 - -
Cefazolin
+
 +
+
+ +
Cefepime
+
 97#
99#
99# 100
Ceftazidime
+/-
 +/-
+/-
 +/- +/-
Ceftriaxone
95#
 97#
97#
 99# 99#
Cefuroxime
86
 86
93
97 91
Ciprofloxacin
+/-
 +/-
+/-
 +/- +/-
Clarithromycin
+
 +
+
 + +
Clindamycin
90
 88
96
 92 91
Doxycycline
86
 86
89
 93 83
Erythromycin
72
 73
76
 86 72
Gentamicin
-
 -
-
 - -
Imipenem
+
 +
+
 + +
Levofloxacin 98 99 99 100 100
Meropenem 88 88 95 97 94
Moxifloxacin + + + + +
Nitrofurantoin & & & & &
Oxacillin/Naf + + + + +
Penicillin 75# 73# 81# 92# 81#
Piperacillin + + + + +
Piperacillin/tazo + + + + +
Ticarcillin/Clav + + + + +
Tobramycin - - - - -
TMP/SMX 78 84 85 89 90
Unasyn/Aug 97 95 100 + 100
Vancomycin 100 100 100 100 100
       
# Tested 147 143 105 73 82

Comments:   # Percent susceptible by meningitis criteria; other drug susceptibilities are by bloodstream criteria

 

Numeric data represent local susceptibility data.
(+) = usually effective or >60% susceptible; (+/-) = clinical trials lacking or 30-60% susceptible; (-) = not effective clinically or <30% susceptible - Adapted with permission from The Sanford Guide to Antimicrobial Therapy
(*) Local (non-Sanford Guide) opinion
(S) = synergistic with penicillin/ampicillin;
(&) nitrofurantoin only useful for lower tract urinary tract infections